Lead: Nick Turner
Phase: 1
| Articles (49) |
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Title: Conversion of Aldoses to Valuable ω-Amino Alcohols Using Amine Transaminase Biocatalysts (2018)
Authors (7): K. Butler, R. Cairns, T. Clarke, A. Gomm, E. Kulcinskaja, E. O'Reilly, J. Ryan ACS Catalysis DOI: 10.1021/acscatal.8b04564 article-journal Themes: Biocatalysis (2019) |
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Title: Molecular Basis of Class A β-Lactamase Inhibition by Relebactam (2019)
Authors (7): J. üR. Brem, P. Hinchliffe, P. A. Lang, A. J. Mulholland, C. J. Schofield, J. Spencer, C. L. Tooke Antimicrobial Agents and Chemotherapy DOI: 10.1128/aac.00564-19 article-journal Themes: Biocatalysis (2020) |
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Title: Emergence of a Negative Activation Heat Capacity during Evolution of a Designed Enzyme (2019)
Authors (7): H. A. Bunzel, D. Hilvert, H. Kries, L. Marchetti, P. R. E. .Mittl, A. J. Mulholland, C. Zeymer Journal of the American Chemical Society DOI: 10.1021/jacs.9b02731 article-journal Themes: Biocatalysis (2019) |
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Title: Projector-Based Embedding Eliminates Density Functional Dependence for QM/MM Calculations of Reactions in Enzymes and Solution (2019)
Authors (8): S. J. Bennie, N. Lawan, S. J. Macrae, F. R. Manby, A. J. Mulholland, K. E. Ranaghan, D. Shchepanovska, J. Zurek Journal of Chemical Information and Modeling DOI: 10.1021/acs.jcim.8b00940 article-journal Themes: Biocatalysis (2019) |
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Title: Alcohol Dehydrogenase‐Triggered Oxa‐Michael Reaction for the Asymmetric Synthesis of Disubstituted Tetrahydropyrans and Tetrahydrofurans (2019)
Authors (5): V. Caprio, H. Eastman, B. Maciá, E. O'Reilly, J. Ryan ChemCatChem DOI: 10.1002/cctc.201900658 article-journal Themes: Biocatalysis (2019) |
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Title: Catalytic and biophysical investigation of rhodium hydroformylase (2019)
Authors (7): C. C. R. .Allen, I. Baig, V. Celorrio, H. T. Imam, A. G. Jarvis, P. C. J. .Kamer, A. C. Marr Catalysis Science & Technology DOI: 10.1039/c9cy01679a article-journal Themes: Biocatalysis (2019) |
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Title: From Bugs to Bioplastics: Total (+)-Dihydrocarvide Biosynthesis by Engineered Escherichia coli (2019)
Authors (5): G. A. Ascue Avalos, H. L. Messiha, N. S. Scrutton, S. Tait, H. S. Toogood ChemBioChem DOI: 10.1002/cbic.201800606 article-journal Themes: Biocatalysis (2019) |
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Title: Chemo-enzymatic routes towards the synthesis of bio-based monomers and polymers (2019)
Authors (3): S. T. Ahmed, N. G. H. .Leferink, N. S. Scrutton Molecular Catalysis DOI: 10.1016/j.mcat.2019.01.036 article-journal Themes: Biocatalysis (2019) |
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Title: Two 3′-O-β-glucosylated nucleoside fluorometabolites related to nucleocidin in Streptomyces calvus (2019)
Authors (5): X. Feng, D. Bello, P. T. Lowe, J. Clark, D. O'Hagan Chemical Science DOI: 10.1039/c9sc03374b article-journal Themes: Biocatalysis (2020) |
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Title: Quantum Mechanics/Molecular Mechanics Simulations Show Saccharide Distortion is Required for Reaction in Hen Egg‐White Lysozyme (2018)
Authors (4): M. A. L. .Limb, R. Suardíaz, I. M. Grant, A. J. Mulholland Chemistry - A European Journal DOI: 10.1002/chem.201805250 article-journal Themes: Biocatalysis (2018) |
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Title: Simplified lipid II-binding antimicrobial peptides: Design, synthesis and antimicrobial activity of bioconjugates of nisin rings A and B with pore-forming peptides (2018)
Authors (5): S. A. Mitchell, F. Truscott, R. Dickman, J. Ward, A. B. Tabor Bioorganic & Medicinal Chemistry DOI: 10.1016/j.bmc.2018.10.015 article-journal Themes: Biocatalysis (2018) |
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Title: Artificial Metalloenzymes as Catalysts for Oxidative Lignin Degradation (2018)
Authors (7): M. V. Doble, A. G. Jarvis, A. C. C. .Ward, J. D. Colburn, J. P. Götze, M. Bühl, P. C. J. .Kamer ACS Sustainable Chemistry & Engineering DOI: 10.1021/acssuschemeng.8b03568 article-journal Themes: Biocatalysis (2018) |
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Title: Application of “Smart” Amine Donors for Rapid Screening and Scale-Up of Transaminase-Mediated Biotransformations (2018)
Authors (8): A. Gomm, S. Grigoriou, C. Peel, J. Ryan, N. Mujtaba, T. Clarke, E. Kulcinskaja, E. O'Reilly European Journal of Organic Chemistry DOI: 10.1002/ejoc.201800799 article-journal Themes: Biocatalysis (2018) |
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Title: QM/MM simulations identify the determinants of catalytic activity differences between type II dehydroquinase enzymes (2018)
Authors (4): E. Lence, M. W. van der Kamp, C. González-Bello, A. J. Mulholland Organic & Biomolecular Chemistry DOI: 10.1039/c8ob00066b article-journal Themes: Biocatalysis (2018) |
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Title: Concise synthesis of artemisinin from a farnesyl diphosphate analogue (2018)
Authors (4): X. Tang, M. Demiray, T. Wirth, R. K. Allemann Bioorganic & Medicinal Chemistry DOI: 10.1016/j.bmc.2017.03.068 article-journal Themes: Biocatalysis (2018) |
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Title: Biocatalytic Routes to Lactone Monomers for Polymer Production (2018)
Authors (10): H. L. Messiha, S. T. Ahmed, V. Karuppiah, R. Suardíaz, G. A. Ascue Avalos, N. Fey, S. Yeates, H. S. Toogood, A. J. Mulholland, N. S. Scrutton Biochemistry DOI: 10.1021/acs.biochem.8b00169 article-journal Themes: Biocatalysis (2018) |
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Title: P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping (2018)
Authors (17): C. G. Acevedo-Rocha, C. G. Gamble, R. Lonsdale, A. Li, N. Nett, S. Hoebenreich, J. B. Lingnau, C. Wirtz, C. Fares, H. Hinrichs, A. Deege, A. J. Mulholland, Y. Nov, D. Leys, K. J. McLean, A. W. Munro, M. T. Reetz ACS Catalysis DOI: 10.1021/acscatal.8b00389 article-journal Themes: Biocatalysis (2018) |
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Title: Discovery, Characterization, Engineering, and Applications of Ene-Reductases for Industrial Biocatalysis (2018)
Authors (2): H. S. Toogood, N. S. Scrutton ACS Catalysis DOI: 10.1021/acscatal.8b00624 article-journal Themes: Biocatalysis (2018) |
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Title: A Noncanonical Proximal Heme Ligand Affords an Efficient Peroxidase in a Globin Fold (2018)
Authors (6): M. Pott, T. Hayashi, T. Mori, P. R. E. .Mittl, A. P. Green, D. Hilvert Journal of the American Chemical Society DOI: 10.1021/jacs.7b12621 article-journal Themes: Biocatalysis (2018) |
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Title: Concurrent Biocatalytic Oxidation and C–C Bond Formation via Gold Catalysis: One-Pot Alkynylation of N-Alkyl Tetrahydroisoquinolines (2018)
Authors (3): M. Odachowski, M. F. Greaney, N. J. Turner ACS Catalysis DOI: 10.1021/acscatal.8b03169 article-journal Themes: Biocatalysis (2018) |
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Title: Enzyme Activity by Design: An Artificial Rhodium Hydroformylase for Linear Aldehydes (2017)
Authors (7): A. G. Jarvis, L. Obrecht, P. J. Deuss, W. Laan, E. K. Gibson, P. P. Wells, P. C. J. .Kamer Angewandte Chemie International Edition DOI: 10.1002/anie.201705753 article-journal Themes: Biocatalysis (2017), Design (2017), Energy (2017), BAG (2017) |
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Title: Optimising Terpene Synthesis with Flow Biocatalysis (2017)
Authors (3): X. Tang, R. K. Allemann, T. Wirth European Journal of Organic Chemistry DOI: 10.1002/ejoc.201601388 article-journal Themes: Biocatalysis (2017) |
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Title: An Efficient Chemoenzymatic Synthesis of Dihydroartemisinic Aldehyde (2017)
Authors (5): M. Demiray, X. Tang, T. Wirth, J. A. Faraldos, R. K. Allemann Angewandte Chemie International Edition DOI: 10.1002/anie.201609557 article-journal Themes: Biocatalysis (2017) |
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Title: Rapid Estimation of Catalytic Efficiency by Cumulative Atomic Multipole Moments: Application to Ketosteroid Isomerase Mutants (2017)
Authors (4): W. Beker, M. W. van der Kamp, A. J. Mulholland, W. A. Sokalski Journal of Chemical Theory and Computation DOI: 10.1021/acs.jctc.6b01131 article-journal Themes: Biocatalysis (2017) |
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Title: Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1 (2017)
Authors (21): P. Hinchliffe, Q. E. Yang, E. Portal, T. Young, H. Li, C. L. Tooke, M. J. Carvalho, N. G. Paterson, J. üR. Brem, P. R. Niumsup, U. Tansawai, L. Lei, M. Li, Z. Shen, Y. Wang, C. J. Schofield, A. J. Mulholland, J. Shen, N. Fey, T. R. Walsh, J. Spencer Scientific Reports DOI: 10.1038/srep39392 article-journal Themes: Biocatalysis (2017) |
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Title: A ruthenium(ii) bis(phosphinophosphinine) complex as a precatalyst for transfer-hydrogenation and hydrogen-borrowing reactions (2017)
Authors (4): R. J. Newland, M. F. .Wyatt, R. L. Wingad, S. M. Mansell Dalton Transactions DOI: 10.1039/c7dt01022b article-journal Themes: Biocatalysis (2017), Environment (2017) |
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Title: Understanding the Role of Designed Solid Acid Sites in the Low-Temperature Production of ϵ-Caprolactam (2017)
Authors (8): M. E. Potter, S. Chapman, A. J. O'Malley, A. Levy, M. Carravetta, T. M. Mezza, S. F. Parker, R. Raja ChemCatChem DOI: 10.1002/cctc.201700516 article-journal Themes: Design (2017), Biocatalysis (2017) |
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Title: Deactivation study of the hydrodeoxygenation of p -methylguaiacol over silica supported rhodium and platinum catalysts (2017)
Authors (7): F. P. .Bouxin, X. Zhang, I. N. .Kings, A. F. Lee, M. J. .H. .Simmons, K. Wilson, S. D. .Jackson Applied Catalysis A: General DOI: 10.1016/j.apcata.2017.03.039 article-journal Themes: Energy (2017), Biocatalysis (2017) |
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Title: Rewiring the “Push-Pull” Catalytic Machinery of a Heme Enzyme Using an Expanded Genetic Code (2020)
Authors (12): M. Ortmayer, K. Fisher, J. Basran, E. M. Wolde-Michael, D. J. Heyes, C. Levy, S. L. Lovelock, J. L. . R. Anderson, E. L. Raven, S. Hay, S. E. J. .Rigby, A. P. Green ACS Catalysis DOI: 10.1021/acscatal.9b05129 article-journal Themes: Biocatalysis (2020) |
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Title: Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases (2020)
Authors (9): J. Mangas-Sanchez, M. Sharma, S. C. Cosgrove, J. I. Ramsden, J. R. Marshall, T. W. Thorpe, R. B. Palmer, G. Grogan, N. J. Turner Chemical Science DOI: 10.1039/d0sc02253e article-journal Themes: Biocatalysis (2020) |
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Title: Small Changes in Hydration Determine Cephalosporinase Activity of OXA-48 β-Lactamases (2020)
Authors (4): V. H. A. .Hirvonen, A. J. Mulholland, J. Spencer, M. W. van der Kamp ACS Catalysis DOI: 10.1021/acscatal.0c00596 article-journal Themes: Biocatalysis (2020) |
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Title: Asymmetric Construction of Alkaloids by Employing a Key ω‐Transaminase Cascade (2020)
Authors (6): F. Taday, J. Ryan, S. P. Argent, V. Caprio, B. Maciá, E. O'Reilly Chemistry - A European Journal DOI: 10.1002/chem.202000067 article-journal Themes: Biocatalysis (2020) |
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Title: Enantioselective Synthesis of Chiral Vicinal Amino Alcohols Using Amine Dehydrogenases (2019)
Authors (9): F. -F. Chen, S. C. Cosgrove, W. R. Birmingham, J. Mangas-Sanchez, J. Citoler, M. P. Thompson, G. -W. Zheng, J. -H. Xu, N. J. Turner ACS Catalysis DOI: 10.1021/acscatal.9b03889 article-journal Themes: Biocatalysis (2019) |
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Title: Enlighten2: molecular dynamics simulations of protein–ligand systems made accessible (2020)
Authors (2): K. Zinovjev, M. W. van der Kamp Bioinformatics DOI: 10.1093/bioinformatics/btaa643 article-journal Themes: Biocatalysis (2020) |
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Title: Teaching Enzyme Catalysis Using Interactive Molecular Dynamics in Virtual Reality (2019)
Authors (7): S. J. Bennie, K. E. Ranaghan, H. M. Deeks, H. E. Goldsmith, M. B. O’Connor, A. J. Mulholland, D. R. Glowacki Journal of Chemical Education DOI: 10.1021/acs.jchemed.9b00181 journal-article Themes: Biocatalysis (2019) |
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Title: Immobilised Enzymes for Sesquiterpene Synthesis in Batch and Flow Systems (2020)
Authors (4): D. Valikhani, P. L. Srivastava, R. K. Allemann, T. Wirth ChemCatChem DOI: 10.1002/cctc.201902135 journal-article Themes: Biocatalysis (2020) |
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Title: Resistance to the “last resort” antibiotic colistin: a single-zinc mechanism for phosphointermediate formation in MCR enzymes (2020)
Authors (13): E. Lythell, R. Suardíaz, P. Hinchliffe, C. Hanpaibool, S. Visitsatthawong, A. S. F. .Oliveira, E. J. M. .Lang, P. Surawatanawong, V. S. Lee, T. Rungrotmongkol, N. Fey, J. Spencer, A. J. Mulholland Chemical Communications DOI: 10.1039/d0cc02520h journal-article Themes: Biocatalysis (2020) |
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Title: Benchmarking quantum mechanical methods for calculating reaction energies of reactions catalyzed by enzymes (2020)
Authors (5): J. Sirirak, N. Lawan, M. W. van der Kamp, J. N. Harvey, A. J. Mulholland PeerJ Physical Chemistry DOI: 10.7717/peerj-pchem.8 journal-article Themes: Biocatalysis (2020) |
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Title: Catalytic mechanism of the colistin resistance protein MCR-1 (2021)
Authors (7): R. Suardíaz, E. Lythell, P. Hinchliffe, M. W. van der Kamp, J. Spencer, N. Fey, A. J. Mulholland Organic & Biomolecular Chemistry DOI: 10.1039/d0ob02566f journal-article Themes: Biocatalysis (2021) |
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Title: Evolution of dynamical networks enhances catalysis in a designer enzyme (2021)
Authors (6): H. A. Bunzel, J. L. . R. Anderson, D. Hilvert, V. L. Arcus, M. W. van der Kamp, A. J. Mulholland Nature Chemistry DOI: 10.1038/s41557-021-00763-6 journal-article Themes: Biocatalysis (2021) |
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Title: Structural basis of terephthalate recognition by solute binding protein TphC (2021)
Authors (10): T. Gautom, D. Dheeman, C. Levy, T. Butterfield, G. Alvarez Gonzalez, P. Le Roy, L. Caiger, K. Fisher, L. Johannissen, N. Dixon Nature Communications DOI: 10.1038/s41467-021-26508-0 journal-article Themes: Biocatalysis (2021) |
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Title: Multiscale Workflow for Modeling Ligand Complexes of Zinc Metalloproteins (2021)
Authors (8): Z. Yang, R. M. Twidale, S. Gervasoni, R. Suardíaz, C. K. Colenso, E. J. M. .Lang, J. Spencer, A. J. Mulholland Journal of Chemical Information and Modeling DOI: 10.1021/acs.jcim.1c01109 journal-article Themes: Biocatalysis (2021) |
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Title: Multiscale Simulations Identify Origins of Differential Carbapenem Hydrolysis by the OXA-48 β-Lactamase (2022)
Authors (5): V. H. A. .Hirvonen, T. M. Weizmann, A. J. Mulholland, J. Spencer, M. W. van der Kamp ACS Catalysis DOI: 10.1021/acscatal.1c05694 journal-article Themes: Biocatalysis (2022) |
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Title: Enzyme evolution and the temperature dependence of enzyme catalysis (2020)
Authors (4): V. L. Arcus, M. W. van der Kamp, C. R. Pudney, A. J. Mulholland Current Opinion in Structural Biology DOI: 10.1016/j.sbi.2020.06.001 journal-article Themes: Biocatalysis (2020) |
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Title: Direct Observation of Ammonia Storage in UiO-66 Incorporating Cu(II) Binding Sites (2022)
Authors (21): Y. Ma, W. Lu, X. Han, Y. Chen, I. da Silva, D. Lee, A. M. Sheveleva, Z. Wang, J. Li, W. Li, M. Fan, S. Xu, F. Tuna, E. J. L. .McInnes, Y. Cheng, S. Rudić, P. Manuel, M. D. Frogley, A. J. Ramirez-Cuesta, M. Schröder, S. Yang Journal of the American Chemical Society DOI: 10.1021/jacs.2c00952 journal-article Themes: Biocatalysis (2022) |
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Title: Biocatalysis in Flow for Drug Discovery (2021)
Authors (2): I. Peñafiel, S. C. Cosgrove Topics in Medicinal Chemistry DOI: 10.1007/7355_2021_116 book-chapter Themes: Biocatalysis (2021) |
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Title: Comment on: “Computer Simulations Reveal an Entirely Entropic Activation Barrier for the Chemical Step in a Designer Enzyme” (2023)
Authors (7): A. Lear, J. L. . R. Anderson, D. Hilvert, V. L. Arcus, M. W. van der Kamp, H. A. Bunzel, A. J. Mulholland ACS Catalysis DOI: 10.1021/acscatal.3c01906 journal-article Themes: Biocatalysis (2023) |
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Title: Visualizing the protons in a metalloenzyme electron proton transfer pathway (2020)
Authors (11): H. Kwon, J. Basran, J. M. Devos, R. Suardíaz, M. W. van der Kamp, A. J. Mulholland, T. E. Schrader, A. Ostermann, M. P. Blakeley, P. C. E. .Moody, E. L. Raven Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.1918936117 journal-article Themes: Biocatalysis (2020) |
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Title: One‐Pot Synthesis of Chiral N‐Arylamines by Combining Biocatalytic Aminations with Buchwald–Hartwig N‐Arylation (2020)
Authors (5): S. C. Cosgrove, M. P. Thompson, S. T. Ahmed, F. Parmeggiani, N. J. Turner Angewandte Chemie International Edition DOI: 10.1002/anie.202006246 journal-article Themes: Biocatalysis (2020) |
| Author | Articles | ORCID |
|---|---|---|
| Celorrio, Verónica | 30 | http://orcid.org/0000-0002-2818-3844 |
| Turner, Nicholas J. | 7 | http://orcid.org/0000-0002-8708-0781 |
| Gibson, Emma K. | 59 | http://orcid.org/0000-0002-7839-3786 |
| Wells, Peter P. | 70 | http://orcid.org/0000-0002-0859-9172 |
| O'Malley, Alexander J. | 21 | http://orcid.org/0000-0002-6221-4333 |
| Parker, Stewart F. | 36 | http://orcid.org/0000-0002-3228-2570 |
| Raja, Robert | 23 | http://orcid.org/0000-0002-4161-7053 |
| Xu, Shaojun | 26 | http://orcid.org/0000-0002-8026-8714 |