Authors (19): B. Josephson, C. Fehl, P. G. Isenegger, S. Nadal, T. H. Wright, A. W. J. .Poh, B. J. Bower, A. M. Giltrap, L. Chen, C. Batchelor-McAuley, G. Roper, O. Arisa, J. B. I. .Sap, A. Kawamura, A. J. Baldwin, S. Mohammed, R. G. Compton, V. Gouverneur, B. G. Davis
Themes: Transformations (2020)
DOI: 10.1038/s41586-020-2733-7
Citations: 102
Pub type: article-journal
Publisher: Springer Science and Business Media LLC
Issue: 7826
License: [{"URL"=>"http://www.springer.com/tdm", "start"=>{"date-parts"=>[[2020, 9, 23]], "date-time"=>"2020-09-23T00:00:00Z", "timestamp"=>1600819200000}, "delay-in-days"=>0, "content-version"=>"tdm"}, {"URL"=>"http://www.springer.com/tdm", "start"=>{"date-parts"=>[[2020, 9, 23]], "date-time"=>"2020-09-23T00:00:00Z", "timestamp"=>1600819200000}, "delay-in-days"=>0, "content-version"=>"vor"}]
Publication date(s): 2020/09/24 (print) 2020/09/23 (online)
Pages: 530-537
Volume: 585 Issue: 7826
Journal: Nature
URL: http://dx.doi.org/10.1038/s41586-020-2733-7
| Name | Description | Publised |
|---|---|---|
| Data for 'Light-Driven, Posttranslation Installation of Reactive Protein Side Chains' | C–C side chain alteration within intact proteins has the potential to al... | 2020 |
| Extended Data Fig. 1 Overview of radical side-chain installation and relevant previous literature. | Extended Data Fig. 1 Overview of radical side-chain installation and rel... | 2020 |
| Extended Data Fig. 2 Complementary strategies for mild protein-compatible photoredox reactions. | Extended Data Fig. 2 Complementary strategies for mild protein-compatibl... | 2020 |
| Extended Data Fig. 3 Investigation and optimization of BACED chemistry. | Extended Data Fig. 3 Investigation and optimization of BACED chemistry.... | 2020 |
| Extended Data Fig. 4 Mechanistic investigation of the role of catechol in BACED reactions. | Extended Data Fig. 4 Mechanistic investigation of the role of catechol i... | 2020 |
| Extended Data Fig. 5 Initial experiments without iron using various hydride sources, and optimization study with sodium borohydride for pySOOF. | Extended Data Fig. 5 Initial experiments without iron using various hydr... | 2020 |
| Extended Data Fig. 6 Optimization study of Fe(ii)-mediated protein modification reaction with pySOOF. | Extended Data Fig. 6 Optimization study of Fe(ii)-mediated protein modif... | 2020 |
| Extended Data Fig. 7 Investigations on pySOOF reagent reactivity and on-protein mechanism. | Extended Data Fig. 7 Investigations on pySOOF reagent reactivity and on-... | 2020 |
| Extended Data Fig. 8 Substrate scopes for BACED and pySOOF. | Extended Data Fig. 8 Substrate scopes for BACED and pySOOF.... | 2020 |
| Extended Data Fig. 9 Upscaling of the protein modification with pySOOF and 19F NMR analysis. | Extended Data Fig. 9 Upscaling of the protein modification with pySOOF a... | 2020 |
| Extended Data Fig. 10 Application of difluorinated amino acid-labelled proteins in 19F NMR studies. | Extended Data Fig. 10 Application of difluorinated amino acid-labelled p... | 2020 |
| Extended Data Fig. 11 Effective molarity driven protein–protein crosslinking with electrophile-containing side chains. | Extended Data Fig. 11 Effective molarity driven protein–protein crosslin... | 2020 |
| Supplementary Discussion | Supl. Discussion This file contains Supl. Discussion 1-6 and Supl. Note... | 2020 |
| Reporting summary | Reporting summary... | 2020 |
| Supplementary Tables | Supl. Tables This file contains Supl. Tables 1-37.... | 2020 |
| Supplementary Methods | Supl. Methods This file contains Supl. Methods and Supl. References.... | 2020 |
| Source data Fig. 3 | Source data Fig. 3... | 2020 |
| Source Data Extended Data Fig. 3 | Source Data Extended Data Fig. 3... | 2020 |
| Source Data Extended Data Fig. 5 | Source Data Extended Data Fig. 5... | 2020 |
| Source Data Extended Data Fig. 6 | Source Data Extended Data Fig. 6... | 2020 |